Wenzhou API Dust-Free GMP Sealed Conveying Project for APIs, Zhejiang
A pharmaceutical company faced risks of dust pollution and cross-contamination during powder transport during its API production process, while also meeting GMP standards for sealed production. The company's original manual feeding method was inefficient and environmental cleanliness difficult to control, urgently seeking an efficient, dust-free, and compliant automated conveying system.
Customer pain points
API materials are mostly highly active, high-value powders, and traditional delivery methods have the following issues:
- Dust leakage leads to reduced workshop cleanliness and increases occupational exposure risks for personnel;
- Material residues and cross-contamination affect the quality stability of the medicine;
- There are many manual operation steps, low production efficiency, and difficulty in maintaining batch consistency;
- The equipment cannot meet GMP's strict requirements for sealing, verifiability, and easy cleaning.
Product advantages
To address these pain points, Head Powder's API pneumatic conveying system (dust-free GMP sealed pneumatic conveying) offers the following solutions:
- Fully sealed conveying: Uses positive or negative pressure dense phase pneumatic conveying technology, allowing materials to flow within sealed pipelines, achieving zero leakage and dust-free operation, preventing dust spread from the source.
- Complies with GMP design: The system material is 304/316L stainless steel, with a mirror-polished inner surface and a no-dead corner design, making cleaning and verification convenient; Equipped with an online cleaning (CIP) interface to meet hygiene requirements for pharmaceutical production.
- Relatively precise control: Through PLC and variable frequency control, it achieves relatively accurate adjustment of conveying speed and material-air ratio, helping to ensure uniform and stable material transfer and high batch reproducibility.
- Flexible adaptation: Customizable conveying paths, valves, and separation devices based on API material characteristics (such as fragility, viscosity, moisture absorption), supporting multi-point feeding and multi-product switching.
- High efficiency and energy saving: The dense phase conveying mode uses low-pressure, high-flow airflow, reducing energy consumption by more than 30% compared to traditional dilute phases while minimizing material damage.
This solution has been successfully applied at multiple API production bases in Zhejiang, helping users pass GMP certification audits to upgrade workshop cleanliness from Class D to Class C, increase production efficiency by over 40%, and reduce the risks of manual intervention and product contamination.